Association of BDNF VAL66MET with post-stroke functional recovery
نویسندگان
چکیده
منابع مشابه
Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism.
BACKGROUND Decreased brain-derived neurotrophic factor (BDNF) has been demonstrated in animal models and patients with depression. However, little is known about changes in BDNF in post-stroke depression (PSD). This study investigated the changes in serum BDNF in patients with PSD, and evaluated whether serum concentrations of BDNF were associated with BDNF gene Val66Met polymorphism. METHODS...
متن کاملAn adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke.
Little is known about the influence of genetic diversity on stroke recovery. One exception is the polymorphism in brain derived neurotrophic factor (BDNF), a critical neurotrophin for brain repair and plasticity. Humans have a high-frequency single nucleotide polymorphism (SNP) in the prodomain of the BDNF gene. Previous studies show that the BDNF Val66Met variant negatively affects motor learn...
متن کاملAssociation between the BDNF Val66Met Polymorphism and Chronicity of Depression
OBJECTIVE Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD). METHODS Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces...
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BACKGROUND Relaxin is a peptide hormone that exerts specific effects on cardiovascular system and human brain, leading to the hypothesis that this hormone may play a protective role against CVD and integration and modulation of behavioral activation. We aimed to demonstrate the efficacy of Relaxin on functional recovery of post-stroke patients. METHODS Patients admitted within a Rehabilitatio...
متن کامل[Functional recovery of post stroke patients with hemiparesis after stroke of different aetiology].
INTRODUCTION Medical rehabilitation focuses on improvement of functional recovery in post stroke patients. The aim of the work was to analyze functional recovery in a cohort of post stroke patients with hemiparesis three months after stroke. MATERIAL AND METHODS A prospective, cohort study included 30 patients from the city of Nis aged 40 to 69. The study was conducted at the Department of Ph...
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ژورنال
عنوان ژورنال: Annals of Physical and Rehabilitation Medicine
سال: 2018
ISSN: 1877-0657
DOI: 10.1016/j.rehab.2018.05.047